Banca de QUALIFICAÇÃO: ANTÔNIA LAÍSA OLIVEIRA DA SILVA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : ANTÔNIA LAÍSA OLIVEIRA DA SILVA
DATA : 27/07/2023
HORA: 08:00
LOCAL: Auditório do PRODEPE
TÍTULO:

DEGRADATION OF HYDROXYCHLOROQUINE BY ANODIC OXIDATION USING DIMENSIONALLY STABLE ANODE

PALAVRAS-CHAVES:

Chloroquine degradation, electrochemical degradation, advanced oxidative processes, drug electrooxidation.

PÁGINAS: 36
GRANDE ÁREA: Outra
ÁREA: Ciências Ambientais
RESUMO:

Hydroxychloroquine (HCQ) is a drug indicated for the treatment of malaria, amoebic dysentery and rheumatism, but in recent years it has received prominence for the treatment of Covid-19, even though there is no scientific evidence for its effectiveness. Due to circumstances, its use has been considerably increased, and with it, a greater amount has been released into water bodies. Due to its high recalcitrant potential, methodologies that promote its degradation in water and effluents must be developed. Advanced oxidative processes (AOPs) have been used as an efficient alternative, since they generate reactive and oxidizing free radicals, such as hydroxyl radicals, which can lead to the mineralization of pollutants. Among them, anodic oxidation stands out because it involves the use of the electron as the main reagent. In this work, the objective was to evaluate the degradation of HCQ, using a Ti/TiO2RuO2IrO2 ADE. Different current densities (20, 40 and 60 mA cm-2) and initial pH values of the solution (4.0 to 12.0) were evaluated, and HCQ degradation was evaluated by means of absorbance and COD removal percentages. The results of the applied current density effect showed that as the electric charge increases in the medium, the greater the removal of HCQ, due to the increase in the amount of hydroxyl radicals. The application of 40 mA cm-2 provided satisfactory results and very close to the removal obtained with 60 mA cm-2, removing 87% (k = 7.66 x 10-3 min-1) and 91% (k = 8.87 x 10-3 min-1) of absorbance, respectively. Thus, the current density of 40 mA cm-2 was selected for subsequent studies, aiming at a lower energy demand. The study of the pH effect of the initial HCQ solution showed that the acidic and neutral media promote greater efficiency of the drug degradation process. The COD removal percentages were 53% and 57% when the pH values of the HCQ solution were 4.0 and 6.8, respectively; at basic pH this removal decreased considerably. The results show that anodic oxidation is an appropriate alternative to apply in the degradation of HCQ in contaminated environmental samples.

MEMBROS DA BANCA:
Interno - 12768 - KEURISON FIGUEREDO MAGALHÃES
Interno - 13136 - LEANDRO BEZERRA DE LIMA
Presidente - 2470 - SUELY SOUZA LEAL DE CASTRO