Banca de QUALIFICAÇÃO: NAYONARA YASMIN ALVES DA SILVA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : NAYONARA YASMIN ALVES DA SILVA
DATA : 22/07/2022
HORA: 15:30
LOCAL: meet.google.com/hhu-ubiy-ube
TÍTULO:

ELECTROANALYSIS OF HYDROXYCHLOROQUINE IN RIVER WATER USING PRINTED CARBON ELECTRODE MODIFIED WITH SILVER NANOPARTICLES

PALAVRAS-CHAVES:

Disposable electrode; hydroxychloroquine determination; electrochemical sensor

PÁGINAS: 46
GRANDE ÁREA: Outra
ÁREA: Ciências Ambientais
RESUMO:

Hydroxychloroquine (HCQ) is part of the 4-aminoquinolines group and is used in the prevention of various diseases such as malaria and dermatological diseases. Large amounts of HCQ are used all over the world due to its wide range of characteristics. But its widespread use can lead to contamination of aquatic systems. Thus, the diagnosis and monitoring of its concentration in river waters and for human consumption is very important. Currently, HCQ analyzes have been performed using chromatographic or spectrometric techniques, however, these techniques have some disadvantages such as high cost, sample preparation and measurements cannot be performed in loco. Alternatively, electrochemical methods are promising because of their advantages, such as simplicity, sensitivity, low cost, miniaturization and the analysis can be done in loco. In this work, an electroanalytical methodology was developed for the determination of HCQ in river water, using printed carbon electrodes modified with silver nanoparticles (EIC/AgNPs). Electrochemical characterization of HCQ on EIC/AgNPs was done using cyclic voltammetry and analysis using chronoamperometry; the effect of pH was evaluated (2.0, 4.0, 6.0, 7.0, 8.0, 10.0 and 12.0), showing that the electrochemical process is pH dependent and is reproducible at more acidic pH. A scan velocity variation study (v = 10, 25, 50, 100, 250 and 500 mV s-1) was carried out to assess the degree of reversibility and mass transport of the sensor. It was observed that the process is irreversible and that the redox process of HCQ in EIC/AgNPs was diffusion controlled. The analytical procedure proved to be sensitive, with detection and quantification limits of 7.2x10-8 mol L-1 and 2.4x10-7 mol L-1 , respectively. The method was successfully applied to the determination of HCQ in contaminated river water samples, with recovery values ranging from 97.5% to 104%.

MEMBROS DA BANCA:
Externa à Instituição - MARIA DE LARA PALMEIRA DE MACEDO ARGUELHO
Externo ao Programa - 12768 - KEURISON FIGUEREDO MAGALHÃES
Presidente - 2470 - SUELY SOUZA LEAL DE CASTRO