Banca de DEFESA: GABRIELLA HELLOYDE DE MORAIS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : GABRIELLA HELLOYDE DE MORAIS
DATA : 19/05/2023
HORA: 14:30
LOCAL: Videoconferência
TÍTULO:

PREPARATION, CHEMICAL AND GENOTOXICOLOGICAL EVALUATION OF LIQUID SOAP BASED ON ESSENTIAL OIL Lippia grata.

PALAVRAS-CHAVES:

Lippia grata; Essencial Oils; Toxicity; Antibacterials; Natural Product.

PÁGINAS: 47
GRANDE ÁREA: Outra
ÁREA: Ciências Ambientais
RESUMO:

The Lippia grata species, belonging to the Verbenaceae family, native to the caatinga and is a producer of essential oils with several therapeutic properties, among them, antimicrobial, anti-inflammatory and anti-proliferative activity are proven. Essential oils can be used in the cosmetics and pharmacology industries, as they are endowed with bioactive compounds, used mainly in perfumery. Therefore, this work aimed to develop a liquid soap based on L. grata oil, evaluating the antifungal efficacy and genotoxicity of the product. However, through the chemical composition of L. grata oil, it was possible to find the compound caryophyllene oxide in a retention time of 21.379, being characterized as the major component and presenting a content of 32.51%. Regarding thermal stability, the oil of L. grata was stable and resistant to high temperatures, preventing the material from decomposing. The elaborate soap had evidence of cytotoxicity and genotoxicity, especially with the concentration of oil at 1%, unlike the concentration of 0.5% of the oil, which showed a low mitotic index. Subsequently, regardless of the soap without essential oil and concentrations (0.5% and 1%) tested for the antifungal analysis, the soap showed a fungicidal action for 100% of the dermatophyte strains and fungistatic for 100% of the Candida albicans strains, i.e. that is, the product made with L. grata oil was able to cause cell death in all dermatophyte strains and only inhibited microbial growth in Candida albicans strains. The development of a liquid soap with essential oils of L. grata with antimicrobial properties would be a viable possibility to ensure antiseptic efficacy, thus presenting it as an alternative to conventional soaps.

MEMBROS DA BANCA:
Externa à Instituição - VÂNIA SOUZA ANDRADE - UFRN
Presidente - 3396 - CYNTHIA CAVALCANTI DE ALBUQUERQUE
Externa ao Programa - 1635 - FRANCISCA MARTA MACHADO CASADO DE ARAÚJO